DEPARTMENT OF CHEMISTRY

Affiliations

Chemistry of Life Processes Institute (CLP)

Research Statement

Our collaborative and interdisciplinary program is at the forefront of the discovery of new catalytic reactions and their application in medicine and energy. Specifically, we have pioneered the use of small organic molecules as catalysts in a multitude of high value chemical transformations. These processes provide new avenues for molecular construction and offer sustainable advantages to established transition metal catalyzed approaches. In the realm of therapeutic translational science, we are creating new routes to natural products and related analogs with promising activities against cancer and central nervous system disorders.

Selected Publications

Peng, Q.; Gogoi, A. R.; Renteria-Gomez, A.; Gutierrez, O.; Scheidt, K. A.* “Visible-light-induced coupling of carboxylic acids with alcohols/amines via a phosphorous linchpin strategy,” Chem. 2023, 9, 1983-1993.

Rourke, M.J.; Wang, C.T.; Schull, C.R.; Scheidt, K. A.* “Acyl Azolium-Photoredox-Enabled Synthesis of B-keto Sulfides,” ACS Catal. 2023, 13, 7987-7994

Kim, D. R.; Orr, M. J.; Kwong, A. J.; Deibler, K. K.; Munshi, H. H.; Bridges, C. S.; Chen, T. J.; Lacorazza, H. D.; Scheidt, K. A.* Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors,” ACS Me. Chem. Lett. 2023, 14, 606-613

Zhu, J. L.; Schull, C. R.; Tam, A. T.; Renteria-Gomez, A.; Gogoi, A. R.; Gutierrez, O*.; Scheidt, K. A.* “Photoinduced Acylations Via Azolium-Promoted Intermolecular Hydrogen Atom Transfer,” J. Am. Chem. Soc. 2023, 145, 1535–1541.

Byun, S.; Farah, A.O.; Wise, H.R.; Katchmar, A.; Cheong, P.H.-Y; Scheidt, K.A* “Enantioselective Copper-Catalyzed Borylative Amidation of Allenes,”J. Am. Chem. Soc. 2022, 144, 22850–22857.

Liu, Y.; Betori, R. C.; Pagacz, J.; Frost, G. B.; Efimova, E. V.; Wu, D.; Wolfgeher, D. J.; Bryan, T. M.; Cohen, S. B.; Scheidt, K. A.; Kron, S. J. “Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization,” Cell Chem Biol. 2022, 29, 1517-1531.e7.

Orr, M. J.; Cao, A.; Wang, T. C.; Gaisen, A.; Csakai, A.; Friswold, A.; Meltzer, H. Y.; McCorvey, J. A.*; Scheidt, K. A.* “Discovery of Highly Potent Serotonin 5-HT2 Receptor Agonists Inspired by Heteroyohimbine Natural Products,” ACS Med. Chem. Lett. 2022, 3, 648–657.

Bay, A. V.; Farnam, E. J.; Scheidt, K. A.* “Synthesis of Cyclohexanones by a Tandem Photocatalyzed Annulation,” J. Am. Chem. Soc. 2022, 144, 7030–7037